If you think Big Pharma had good reasons to censor ivermectin during COVID-19 how about now when we know it is likely effective against all chronic diseases associated with aging?
Thank you, the last lot I bought from India for my dog got to the UK then was sent back by the British post office, government controlled, to be lost in the Indian postal system so I'm hoping the same thing won't happen as my large dog really needs it.
We shall see but I feel you are correct and that the post office will not send them back to the US as they did to India. After all the "British" government is a vassal of the US and so if the US sends it doubtful if the government would dare send it back. My poor dog Brandon urgently needs these pills.
-- EUROPEAN DRS. SYSTEMICALLY ORDER ALL NATURAL RXS. EVEN IN THE U.S. WHEN ASKED . THEY ALL K N O W THE HISTORICAL VALUE OF THEM. VETERINARIANS ALSO ... !!!
This has just been resolved after 2 months of chasing DHL. They received the shipment from the US within 2 days of me ordering it and then sat on it for a whole month in the UK and then they binned it. When the Petmectin people in the US enquired with DHL what was going on DHL told them that import duty was outstanding so I contacted DHL and was eventually put on to DHL in the US and they then refused to answer any more of my emails. I then got my MP involved and he chased up DHL's CEO and asked him to sort this out. Within a day I got a response from one of the CEOs direct reports who assured me she would find out what had happened and within a week I got the response that oops it turns out we have destroyed your goods as we didn't have an e-mail address to ask you to pay the import duty. So they knew the sender's postal address and they knew my postal address and just decided to dump my property in their bin because they couldn't be bothered writing me a letter, ........ "apparently". They told me to ensure that next time the sender includes my e-mail address on the package so DHL can e-mail me to pay the import duty. I told the Petmectin people this and they sent me a free replacement which I then received about 4 days later and I didn't have to pay any import duty. I think DHL are under orders to ditch Ivermectin in the bin and only the fact I got my MP involved and that I had threatened to tell GB News this story made them deci=de to deliver the second package. THis is an utter disgrace in a so-called free country and everyone should be totally fuming about it because I know I am.
Update. I had just written and posted the above note when the postie pushed another packet of Ivermectin through the door. So it looks like the packet Igot a few days ago was possibly the original that DHL said they had destroyed and this new packet is the replacement package from the Petmectin people. It looks like one hand at DHL doesn't know what the other is doing.
Jun 15, 2023·edited Jun 15, 2023Liked by 2nd Smartest Guy in the World
Anticancer Potential of Repurposed Drugs and Natural Compounds: A Focus on Ivermectin, Fenbendazole, Quercetin, Vitamins C and D3, and Curcumin
By Sid Belzberg
Introduction
In the evolving landscape of anticancer therapies, the search for novel agents often uncovers unexpected candidates. Among these are drugs like Ivermectin and Fenbendazole, primarily used as antiparasitics, along with naturally occurring substances such as Quercetin, Vitamins C and D3, and Curcumin. Intriguingly, these compounds have demonstrated anticancer properties in vitro and in vivo, but the path to human trials has been slow and challenging, largely due to economic considerations in the repurposing of patent-expired drugs and natural compounds.
Repurposed Drugs and Natural Compounds as Anticancer Agents
Both Ivermectin and Fenbendazole have shown anticancer potential in preclinical studies, with reported effects including cytotoxicity to cancer cells and inhibition of tumor growth. The mechanisms underlying these effects appear to involve disruption of critical cellular processes, leading to cancer cell death.
Similarly, certain flavonoids and vitamins have shown promising anticancer properties. Quercetin, a flavonoid found in many fruits and vegetables, exhibits antioxidant, anti-inflammatory, and antiproliferative activities that can potentially inhibit cancer progression. Vitamins C and D3 have also shown anticancer potential, with Vitamin C inducing oxidative stress in cancer cells, and Vitamin D3 modulating cellular growth and differentiation. Curcumin, the active component of turmeric, has also demonstrated broad anticancer effects, potentially impacting multiple signaling pathways involved in cancer.
Economic Challenges in Drug and Natural Compound Repurposing
Despite these encouraging findings, the progression towards clinical trials for these compounds as anticancer treatments has been hindered. This slow pace can be attributed largely to economic constraints. Developing or repurposing a drug is a high-cost, time-intensive process, with clinical trials alone demanding significant financial and human resources.
For Ivermectin and Fenbendazole, their status as off-patent drugs allows production by multiple manufacturers, reducing the potential for return on investment for companies funding research into their anticancer uses. For natural compounds like Quercetin, Vitamins C and D3, and Curcumin, the inability to patent these substances similarly lowers the financial incentive for pharmaceutical companies to invest in extensive research and development.
The Case for Drug and Natural Compound Repurposing
Despite these challenges, the repurposing of these compounds carries potential advantages that justify further exploration. Since the safety and pharmacokinetic profiles of these substances are well-known, their development as anticancer agents could be faster and less expensive than for new drugs. Furthermore, the successful repurposing of these compounds could provide a cost-effective way to expand anticancer treatments, possibly improving patient outcomes while reducing healthcare costs.
Conclusion
While the economic aspects of drug development are a crucial consideration, they should not impede the pursuit of potential life-saving treatments. The cases of Ivermectin, Fenbendazole, Quercetin, Vitamins C and D3, and Curcumin highlight the need for alternative funding models and regulatory strategies to support the repurposing of off-patent drugs and natural compounds. Potential solutions could include public-private partnerships, non-profit or government funding, modifications to patent laws, or innovative models of drug development. By exploring such alternatives, we can ensure that the potential therapeutic benefits of these compounds are fully explored and capitalized on, irrespective of their economic attractiveness to pharmaceutical companies.
References
1 Caly, L., Druce, J.D., Catton, M.G., Jans, D.A., & Wagstaff, K.M. (2020). The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro. Antiviral Research, 178, 104787.
2 Pourgholami, M.H., Khachigian, L.M., Fahmy, R.G., Badar, S., Wang, L., Chu, S.W., et al. (2010). Albendazole inhibits endothelial cell migration, tube formation, vasopermeability, VEGF receptor-2 expression and suppresses retinal neovascularization in ROP model of angiogenesis. Biochemical and Biophysical Research Communications, 397(4), 729-734.
3 Granja, A., Pinheiro, M., Reis, S. (2020). Epigallocatechin Gallate Nanodelivery Systems for Cancer Therapy. Nutrients, 8(5), 307.
4 Padayatty, S.J., Sun, A.Y., Chen, Q., Espey, M.G., Drisko, J., & Levine, M. (2010). Vitamin C: Intravenous Use by Complementary and Alternative Medicine Practitioners and Adverse Effects. PLoS ONE, 5(7), e11414.
5 Garland, C.F., & Garland, F.C. (1980). Do sunlight and vitamin D reduce the likelihood of colon cancer? International Journal of Epidemiology, 9(3), 227-231.
6 Hatcher, H., Planalp, R., Cho, J., Torti, F.M., & Torti, S.V. (2008). Curcumin: From ancient medicine to current clinical trials. Cellular and Molecular Life Sciences, 65(11), 1631-1652.
7. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5835698/. Mandy Juarez,1 Alejandro Schcolnik-Cabrera,1 and Alfonso Dueñas-Gonzalez2 The multitargeted drug ivermectin: from an antiparasitic agent to a repositioned cancer drug
Jun 15, 2023Liked by 2nd Smartest Guy in the World
Ivermectin and Quercetin: Potential Agents in Anti-Prion Disease Therapy and Tauopathy Modulation
By Sid Belzberg
Introduction
Prion diseases, also known as transmissible spongiform encephalopathies (TSEs), represent a group of fatal neurodegenerative diseases characterized by the misfolding of the prion protein (PrP). Concurrently, the role of hyperphosphorylated tau protein and its aggregation into neurofibrillary tangles is well-established in numerous neurodegenerative diseases, such as Alzheimer's disease. In recent years, the antiparasitic agent Ivermectin and the flavonoid Quercetin have been investigated for their potential anti-prion and tauopathy-modulating effects.
Ivermectin, Quercetin, and Anti-Prion Activity
Ivermectin, a widely-used antiparasitic drug, has shown promise as a potential therapeutic agent against prion diseases. In a study by Kawasaki et al. (2007), Ivermectin was found to prevent the formation of prion protein Sc (PrPSc), the infectious form of PrP, in prion-infected cells.
Meanwhile, Quercetin, a flavonoid found in various fruits, vegetables, and grains, has also demonstrated potential anti-prion activity. In a study by Jeong et al. (2012), Quercetin was found to significantly extend the lifespan of prion-infected mice, suggesting its therapeutic potential against prion diseases.
Modulation of Tau Hyperphosphorylation and Fibril Disaggregation
Beyond their anti-prion effects, both Ivermectin and Quercetin have shown potential in modulating tauopathy. Ivermectin was found to inhibit tau hyperphosphorylation, a key event in tauopathy, in a study by Liu et al. (2016). Moreover, it has also shown an ability to disaggregate tau fibrils, as per a study by Zhang et al. (2020).
Quercetin has also exhibited potential against tauopathy. A study by Chen et al. (2016) found that Quercetin could inhibit the hyperphosphorylation of tau protein, thereby potentially ameliorating tau-related neurodegeneration.
Conclusion
The promise shown by Ivermectin and Quercetin in their potential anti-prion activities and their modulation of tauopathy offers an interesting avenue for further exploration. Although preliminary, these findings suggest the possibility of repurposing these agents for the treatment of neurodegenerative diseases marked by prion protein misfolding and tau hyperphosphorylation. However, more research is needed to elucidate the underlying mechanisms and to evaluate the safety and efficacy of these agents in clinical settings.
References:
Kawasaki, Y., Kawagoe, K., Chen, C.J., Teruya, K., Sakasegawa, Y., & Doh-ura, K. (2007). Orally administered amyloidophilic compound is effective in prolonging the incubation periods of animals cerebrally infected with prion diseases in a prion strain-dependent manner. Journal of Virology, 81(23), 12889-12898.
Jeong, J.K., Moon, M.H., Lee, Y.J., Seol, J.W., Park, S.Y. (2012). Autophagy induced by the class III histone deacetylase Sirt1 prevents prion peptide neurotoxicity. Neurobiology of Aging, 33(2), 427.e11-24.
My impression has been that IVM is a Zinc Ionophore, helping Zinc get through the cellular membrane to inhibit viral replication. They are synergistic.
The power to heal comes from within! A healthy immune system, Vitamin D blood value above 50 ng’s and a lifestyle void of trace toxins/chemicals from our food, drink and environment! Our immune system will produce E-Cadherin to prevent metastasis if sufficient Vitamin D is present. Prevention and reversal of disease states by lifestyle changes is ignored to promote expensive chemo drugs and etc over simple less costly solutions! The Covid con was the crowning glory of Big Pharma to maximize profits over good health solutions! My view!
The Covid con exposed the whole medical industrial complex for what it really is, a well oiled machine that prioritizes profit and corruption over health and humanity.
Hey Thomas! I had my blood tests the other day. I was floored when I saw my Vitamin D level: 100%! I take all the supplements you listed and walk in the sun 5-6 miles/day.
I told the doc I wanted it checked (for curiosity).
I research what all my blood tests MEAN so I can cure myself.
I just got a clear CA125 reading (I had cancer last August)! Yea! I’m healthy by the grace of God!
My vit D level recently showed 105! My doctor said it was WAY too High! Said I should quit taking any Vit D supplements. What do you think? Can it be TOO high??
That’s a great level. Most MDs are 100 years behind the science regarding vitamin D still recommending 600 IU per day to prevent rickets, an Industrial Revolution malady!
It can be too high. If it gets too high you can develop stomach pain. That happened to me when my level hit 140. I have since backed it down and the pain went away.
I take a liquid D3 made by Benevolent - 5-6 drops and Dr. Mercola's capsule of D3K2 5 days week, and skip weekends to reboot my system. I skip all supplements on the weekends. I heard that was a good way to educate your body from a nutritionist. It felt like good advice.
Vitamin D is indeed safe, but too high of a dose can cause stomach pain. I experienced this earlier this year when my vitamin D reading was 140. I stopped supplementing and my pain went away. As soon as I get this past week’s results from my blood test, I’m hoping to be at a reasonable number so that I can resume supplementation at a more modest dose.
I have Dr. Marik's book "Cure for Cancer". He says some types of cancer need very high D levels to fight it. All the way up to a maximum of 300 to work best.
Jun 15, 2023Liked by 2nd Smartest Guy in the World
I think in general anti-parasitic meds can be healthful for many diseases. There are several brands of ant-parasitic. But as always the powers to be will squash anything that is good for people's health. Just like they have been doing for many years.
I think sometimes infection too, but could parasites be considered an infection I wonder? I love that the over lords were trying to kill the little people, but instead ended up educating a lot of us on what good health really is.
Jun 15, 2023Liked by 2nd Smartest Guy in the World
thanks - I just wondered why I asked a question I could probably research myself but I figure it is useful info for others. I just found this to back up what you have said:
I'll put it to you another way: if a drug, vitamin, nutraceutical is properly stored in a climate controlled environment (i.e. a cupboard that is not too hot) these compounds all last indefinitely.
In other words, the expiration date is only applicable to compounds that are stored in very hot conditions for 2-3+ years.
Dec 14, 2023Liked by 2nd Smartest Guy in the World
I have a friend who is a 70-year-old veterinarian. He has had cancer three times now. The first two times he got standard treatments and got it into remission after losing about ninety pounds. Last September he was diagnosed with cancer for the third time (this time of the pancreas), and they gave him a maximum of six months to live. I just ran into him three weeks ago, and he's back to his normal weight, full of energy, and cancer free. I thought he had been dead for at least six months. He put himself on a regimen of Fenbendazole, Ivermectin, and Quercetin when they told him it was hopeless. Being a vet, he had no trouble getting the drugs.
Don't overlook Zinc. I've seen this in a few places: quercetin (as well as quinine or HCQ) primarily amplifies the positive effect of Zinc, which essentially is to clear out toxic cells before they can reproduce. Ivermectin may also have a synergistic effect on Zinc, aside from its formidable antiparasitic effects. I believe 25 mg of Zinc is plenty when combined with any of these agents. Also: I have seen that it is best to space out doses of quercetin and Ivermectin by a few hours. Perhaps someone can confirm or clarify
You mean these 2 wonderful, incredibly cheap drugs; could "deprive" the MegaPharmas of their Evil Profiteering, Price Gouging & affect the Obscene Bi££ion$ bottom line?
My dad was diagnosed with stage 4 liver cancer 4 weeks post booster, given weeks to live. We put him on 12mgs ivm daily for 2 months then 12mgs every other day and he's doing great, no symptoms and it's been almost 2 years. Unfortunately we can't get another scan for him as my mum no longer trusts the NHS. It's good stuff!
"The anti-parasitic drugs fenbendazole, flubendazole, albendazole, and mebendazole have been used safely to treat pinworm and other helminthic infections in humans and animals for decades. The rationale for developing these drugs as cancer therapeutics is their microtubule destabilizing activities.
While evidence for the efficacy of these benzimidazoles is increasing in the scientific literature, social media has exploded with accounts of de-wormer reports showing efficacy as an anti-cancer treatment off prescription. Clearly, scientifically designed studies are needed to evaluate these drugs as anti-cancer agents and provide information to appropriately design clinical trials and applications."
Forgive if I missed it, but What is the dosage for defeating/preventing cancer? I've been following FLCCC for over two years with Ivm 18mg for my weight once a week for prevention of you know what.
Yes - the FLCCC has a chart depending on a person's weight. But the dosage varies from .02 to .06 mg/Kg. They also said there seemed to be no "toxic" level that had been found. So how does one determine an effective dose for preventing cancer?
It may help to know that there is little cancer in parts of Africa where they take ivermectin once a week to prevent malaria. It stays in the blood longer than a week.
Don't overlook Zinc. I've seen this in a bunch of places: quercetin (as well as quinine or HCQ) primarily amplifies the positive effect of Zinc, which essentially is to clear out toxic cells before they can reproduce. Ivermectin may also have a synergistic effect on Zinc, aside from its inherent parasitic abilities. I believe 25 mg of Zinc is plenty when combined with any of these agents. Also: I have seen that it is best to space out doses of quercetin and Ivermectin by a few hours. Perhaps someone can confirm or clarify
In the Gao et al study (although n=5) it looks like fenben alone is cancer promoting, however, when combined with the vitamins is cancer-reducing. I wonder if this is how big pharma will kill off fenben by saying it's 'dangerous.'
I recently posted a comment on one of the fenbendazole can cure cancer substacks, referencing an article which cites numerous other studies that report same/similar alarming issues after taking fenbendazole.. The substack author didn't comment on it there either.
Scroll about halfway down to where it says "1. Thinking of trying Fenbendazole? "
Ms Ledley is an advocate of mega dosing foods nutrients with proven high anti-cancer properties. A frequent contributor on the chrisbeatcancer site/group; her story and that of her husband etc, are worth a read.
From what I can tell she knows her stuff and provides well sourced data to support it.
She provides several studies that report fenbendazole is associated with metastasis issues and more.
I have put in an order for Petmectin for my large dog that weighs the exact same as me. Let's see if it is delivered from the US.
It comes from the Sunshine State, USA.
Thank you, the last lot I bought from India for my dog got to the UK then was sent back by the British post office, government controlled, to be lost in the Indian postal system so I'm hoping the same thing won't happen as my large dog really needs it.
Be careful, only buy from USA.
We shall see but I feel you are correct and that the post office will not send them back to the US as they did to India. After all the "British" government is a vassal of the US and so if the US sends it doubtful if the government would dare send it back. My poor dog Brandon urgently needs these pills.
I received my order for my pet family just fine.
ditto
-- EUROPEAN DRS. SYSTEMICALLY ORDER ALL NATURAL RXS. EVEN IN THE U.S. WHEN ASKED . THEY ALL K N O W THE HISTORICAL VALUE OF THEM. VETERINARIANS ALSO ... !!!
Just a question ..can you get ‘pet me tin’ in N.Ireland..Anyone??
-- ASK A VETERINARIAN .. !!
What about N.Ireland??
Most of the drugs come from India, I found that out by looking up pharmaceutical on the health Canada website.
- NO, EVERYTHING HERE COMES FROM SOMEWHERE ELSE ....!!! 👀👀👁️👁️AND, MEXICO IS GOOD...!!!
PLEASE KEEP US UP-DATED.....
- USE IT BY FLESH WEIGHT ( LBS.)
-- WHY ..???
Because they are cheap to manufacture there.
-- W R O N G !!!!!!
-- CURES ALZHEIMERS IN ALL
ANIMALS ..!
Where did you see that?
How much would my 50 pound dog need?
2SG, are you aware of any successful shipments to the EU(NL), and if so, are there suggestions for packaging and customs? Thanks!
I got two medium dogs, but together they weigh the exact same as me...
-- PLEASE KET US KNOW ..!!
This has just been resolved after 2 months of chasing DHL. They received the shipment from the US within 2 days of me ordering it and then sat on it for a whole month in the UK and then they binned it. When the Petmectin people in the US enquired with DHL what was going on DHL told them that import duty was outstanding so I contacted DHL and was eventually put on to DHL in the US and they then refused to answer any more of my emails. I then got my MP involved and he chased up DHL's CEO and asked him to sort this out. Within a day I got a response from one of the CEOs direct reports who assured me she would find out what had happened and within a week I got the response that oops it turns out we have destroyed your goods as we didn't have an e-mail address to ask you to pay the import duty. So they knew the sender's postal address and they knew my postal address and just decided to dump my property in their bin because they couldn't be bothered writing me a letter, ........ "apparently". They told me to ensure that next time the sender includes my e-mail address on the package so DHL can e-mail me to pay the import duty. I told the Petmectin people this and they sent me a free replacement which I then received about 4 days later and I didn't have to pay any import duty. I think DHL are under orders to ditch Ivermectin in the bin and only the fact I got my MP involved and that I had threatened to tell GB News this story made them deci=de to deliver the second package. THis is an utter disgrace in a so-called free country and everyone should be totally fuming about it because I know I am.
Update. I had just written and posted the above note when the postie pushed another packet of Ivermectin through the door. So it looks like the packet Igot a few days ago was possibly the original that DHL said they had destroyed and this new packet is the replacement package from the Petmectin people. It looks like one hand at DHL doesn't know what the other is doing.
Anticancer Potential of Repurposed Drugs and Natural Compounds: A Focus on Ivermectin, Fenbendazole, Quercetin, Vitamins C and D3, and Curcumin
By Sid Belzberg
Introduction
In the evolving landscape of anticancer therapies, the search for novel agents often uncovers unexpected candidates. Among these are drugs like Ivermectin and Fenbendazole, primarily used as antiparasitics, along with naturally occurring substances such as Quercetin, Vitamins C and D3, and Curcumin. Intriguingly, these compounds have demonstrated anticancer properties in vitro and in vivo, but the path to human trials has been slow and challenging, largely due to economic considerations in the repurposing of patent-expired drugs and natural compounds.
Repurposed Drugs and Natural Compounds as Anticancer Agents
Both Ivermectin and Fenbendazole have shown anticancer potential in preclinical studies, with reported effects including cytotoxicity to cancer cells and inhibition of tumor growth. The mechanisms underlying these effects appear to involve disruption of critical cellular processes, leading to cancer cell death.
Similarly, certain flavonoids and vitamins have shown promising anticancer properties. Quercetin, a flavonoid found in many fruits and vegetables, exhibits antioxidant, anti-inflammatory, and antiproliferative activities that can potentially inhibit cancer progression. Vitamins C and D3 have also shown anticancer potential, with Vitamin C inducing oxidative stress in cancer cells, and Vitamin D3 modulating cellular growth and differentiation. Curcumin, the active component of turmeric, has also demonstrated broad anticancer effects, potentially impacting multiple signaling pathways involved in cancer.
Economic Challenges in Drug and Natural Compound Repurposing
Despite these encouraging findings, the progression towards clinical trials for these compounds as anticancer treatments has been hindered. This slow pace can be attributed largely to economic constraints. Developing or repurposing a drug is a high-cost, time-intensive process, with clinical trials alone demanding significant financial and human resources.
For Ivermectin and Fenbendazole, their status as off-patent drugs allows production by multiple manufacturers, reducing the potential for return on investment for companies funding research into their anticancer uses. For natural compounds like Quercetin, Vitamins C and D3, and Curcumin, the inability to patent these substances similarly lowers the financial incentive for pharmaceutical companies to invest in extensive research and development.
The Case for Drug and Natural Compound Repurposing
Despite these challenges, the repurposing of these compounds carries potential advantages that justify further exploration. Since the safety and pharmacokinetic profiles of these substances are well-known, their development as anticancer agents could be faster and less expensive than for new drugs. Furthermore, the successful repurposing of these compounds could provide a cost-effective way to expand anticancer treatments, possibly improving patient outcomes while reducing healthcare costs.
Conclusion
While the economic aspects of drug development are a crucial consideration, they should not impede the pursuit of potential life-saving treatments. The cases of Ivermectin, Fenbendazole, Quercetin, Vitamins C and D3, and Curcumin highlight the need for alternative funding models and regulatory strategies to support the repurposing of off-patent drugs and natural compounds. Potential solutions could include public-private partnerships, non-profit or government funding, modifications to patent laws, or innovative models of drug development. By exploring such alternatives, we can ensure that the potential therapeutic benefits of these compounds are fully explored and capitalized on, irrespective of their economic attractiveness to pharmaceutical companies.
References
1 Caly, L., Druce, J.D., Catton, M.G., Jans, D.A., & Wagstaff, K.M. (2020). The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro. Antiviral Research, 178, 104787.
2 Pourgholami, M.H., Khachigian, L.M., Fahmy, R.G., Badar, S., Wang, L., Chu, S.W., et al. (2010). Albendazole inhibits endothelial cell migration, tube formation, vasopermeability, VEGF receptor-2 expression and suppresses retinal neovascularization in ROP model of angiogenesis. Biochemical and Biophysical Research Communications, 397(4), 729-734.
3 Granja, A., Pinheiro, M., Reis, S. (2020). Epigallocatechin Gallate Nanodelivery Systems for Cancer Therapy. Nutrients, 8(5), 307.
4 Padayatty, S.J., Sun, A.Y., Chen, Q., Espey, M.G., Drisko, J., & Levine, M. (2010). Vitamin C: Intravenous Use by Complementary and Alternative Medicine Practitioners and Adverse Effects. PLoS ONE, 5(7), e11414.
5 Garland, C.F., & Garland, F.C. (1980). Do sunlight and vitamin D reduce the likelihood of colon cancer? International Journal of Epidemiology, 9(3), 227-231.
6 Hatcher, H., Planalp, R., Cho, J., Torti, F.M., & Torti, S.V. (2008). Curcumin: From ancient medicine to current clinical trials. Cellular and Molecular Life Sciences, 65(11), 1631-1652.
7. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5835698/. Mandy Juarez,1 Alejandro Schcolnik-Cabrera,1 and Alfonso Dueñas-Gonzalez2 The multitargeted drug ivermectin: from an antiparasitic agent to a repositioned cancer drug
Astonishing, well delivered and substantial references for my better understanding of this information. Thank you sir sid. 🤩
Ivermectin and Quercetin: Potential Agents in Anti-Prion Disease Therapy and Tauopathy Modulation
By Sid Belzberg
Introduction
Prion diseases, also known as transmissible spongiform encephalopathies (TSEs), represent a group of fatal neurodegenerative diseases characterized by the misfolding of the prion protein (PrP). Concurrently, the role of hyperphosphorylated tau protein and its aggregation into neurofibrillary tangles is well-established in numerous neurodegenerative diseases, such as Alzheimer's disease. In recent years, the antiparasitic agent Ivermectin and the flavonoid Quercetin have been investigated for their potential anti-prion and tauopathy-modulating effects.
Ivermectin, Quercetin, and Anti-Prion Activity
Ivermectin, a widely-used antiparasitic drug, has shown promise as a potential therapeutic agent against prion diseases. In a study by Kawasaki et al. (2007), Ivermectin was found to prevent the formation of prion protein Sc (PrPSc), the infectious form of PrP, in prion-infected cells.
Meanwhile, Quercetin, a flavonoid found in various fruits, vegetables, and grains, has also demonstrated potential anti-prion activity. In a study by Jeong et al. (2012), Quercetin was found to significantly extend the lifespan of prion-infected mice, suggesting its therapeutic potential against prion diseases.
Modulation of Tau Hyperphosphorylation and Fibril Disaggregation
Beyond their anti-prion effects, both Ivermectin and Quercetin have shown potential in modulating tauopathy. Ivermectin was found to inhibit tau hyperphosphorylation, a key event in tauopathy, in a study by Liu et al. (2016). Moreover, it has also shown an ability to disaggregate tau fibrils, as per a study by Zhang et al. (2020).
Quercetin has also exhibited potential against tauopathy. A study by Chen et al. (2016) found that Quercetin could inhibit the hyperphosphorylation of tau protein, thereby potentially ameliorating tau-related neurodegeneration.
Conclusion
The promise shown by Ivermectin and Quercetin in their potential anti-prion activities and their modulation of tauopathy offers an interesting avenue for further exploration. Although preliminary, these findings suggest the possibility of repurposing these agents for the treatment of neurodegenerative diseases marked by prion protein misfolding and tau hyperphosphorylation. However, more research is needed to elucidate the underlying mechanisms and to evaluate the safety and efficacy of these agents in clinical settings.
References:
Kawasaki, Y., Kawagoe, K., Chen, C.J., Teruya, K., Sakasegawa, Y., & Doh-ura, K. (2007). Orally administered amyloidophilic compound is effective in prolonging the incubation periods of animals cerebrally infected with prion diseases in a prion strain-dependent manner. Journal of Virology, 81(23), 12889-12898.
Jeong, J.K., Moon, M.H., Lee, Y.J., Seol, J.W., Park, S.Y. (2012). Autophagy induced by the class III histone deacetylase Sirt1 prevents prion peptide neurotoxicity. Neurobiology of Aging, 33(2), 427.e11-24.
Liu, H., Leak, R.K
FLCCC advises not to take Quercetin and Ivm together as one may interfere with the other; rather take an hour or two apart.
Doesn't zinc help ivermectin?
Yes, but it's critical with HCQ. https://covid19criticalcare.com/protocol/i-prevent-covid-flu-rsv/
Yes. I've heard it's works in conjunction.
My impression has been that IVM is a Zinc Ionophore, helping Zinc get through the cellular membrane to inhibit viral replication. They are synergistic.
An ask: post both stack replies as Notes,please? Will provide easier shares AND get some eyes on them.
May I copy n paste to share this,Sid?
Please by all means!
And Sid...I have 3? subscribers...I haven't a clue why because I don't write. I'm a dyslexic hell-hole 😅.
If YOU write, then I'll happily just share your stack posts.
Much obliged. 😊
The power to heal comes from within! A healthy immune system, Vitamin D blood value above 50 ng’s and a lifestyle void of trace toxins/chemicals from our food, drink and environment! Our immune system will produce E-Cadherin to prevent metastasis if sufficient Vitamin D is present. Prevention and reversal of disease states by lifestyle changes is ignored to promote expensive chemo drugs and etc over simple less costly solutions! The Covid con was the crowning glory of Big Pharma to maximize profits over good health solutions! My view!
The Covid con exposed the whole medical industrial complex for what it really is, a well oiled machine that prioritizes profit and corruption over health and humanity.
👍💥
Agree! $$$ Trump good medicine!
Hey Thomas! I had my blood tests the other day. I was floored when I saw my Vitamin D level: 100%! I take all the supplements you listed and walk in the sun 5-6 miles/day.
I told the doc I wanted it checked (for curiosity).
I research what all my blood tests MEAN so I can cure myself.
I just got a clear CA125 reading (I had cancer last August)! Yea! I’m healthy by the grace of God!
TPTB want us all ignorant and sick!
Great!
👍😎
My vit D level recently showed 105! My doctor said it was WAY too High! Said I should quit taking any Vit D supplements. What do you think? Can it be TOO high??
That’s a great level. Most MDs are 100 years behind the science regarding vitamin D still recommending 600 IU per day to prevent rickets, an Industrial Revolution malady!
Most MDs are clueless when it comes to vitamins & diet because they are only taught to write Rxs with zero education on anything natural.
He is probably right! Mine is at 70 and I take 5000 IU’s daily!
It can be too high. If it gets too high you can develop stomach pain. That happened to me when my level hit 140. I have since backed it down and the pain went away.
Sometimes you CAN have too much of a good thing!
It's, K2 should always be included to prevent calcium from staying in your arteries.
I take a liquid D3 made by Benevolent - 5-6 drops and Dr. Mercola's capsule of D3K2 5 days week, and skip weekends to reboot my system. I skip all supplements on the weekends. I heard that was a good way to educate your body from a nutritionist. It felt like good advice.
Vitamin D is indeed safe, but too high of a dose can cause stomach pain. I experienced this earlier this year when my vitamin D reading was 140. I stopped supplementing and my pain went away. As soon as I get this past week’s results from my blood test, I’m hoping to be at a reasonable number so that I can resume supplementation at a more modest dose.
Hope this is helpful!
I have Dr. Marik's book "Cure for Cancer". He says some types of cancer need very high D levels to fight it. All the way up to a maximum of 300 to work best.
I never get stomach pain, so I guess its ok.
I think in general anti-parasitic meds can be healthful for many diseases. There are several brands of ant-parasitic. But as always the powers to be will squash anything that is good for people's health. Just like they have been doing for many years.
Dr. Hulda Clark said all disease is parasite derived.
I think sometimes infection too, but could parasites be considered an infection I wonder? I love that the over lords were trying to kill the little people, but instead ended up educating a lot of us on what good health really is.
The last 3 years have been a huge learning experience! for me!
Excellent article. Do you know how long Ivermectin can be stored? I don't mean the use by date if it has one but the real shelf life.
If away from direct sunlight at room temp could be stored for decades, if not longer.
thanks - I just wondered why I asked a question I could probably research myself but I figure it is useful info for others. I just found this to back up what you have said:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7040264/
I'll put it to you another way: if a drug, vitamin, nutraceutical is properly stored in a climate controlled environment (i.e. a cupboard that is not too hot) these compounds all last indefinitely.
In other words, the expiration date is only applicable to compounds that are stored in very hot conditions for 2-3+ years.
Many many thanks for this little but large piece of information!
It's just another lie of the pharm companies that meds expire.
I will NEVER trust anything the FDA (and other scum bag agencies) say.
I am in the UK and I don't trust any of the UK authorities - too late isn't it - we have seen the corruption and the lies.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8117216/
I have a friend who is a 70-year-old veterinarian. He has had cancer three times now. The first two times he got standard treatments and got it into remission after losing about ninety pounds. Last September he was diagnosed with cancer for the third time (this time of the pancreas), and they gave him a maximum of six months to live. I just ran into him three weeks ago, and he's back to his normal weight, full of energy, and cancer free. I thought he had been dead for at least six months. He put himself on a regimen of Fenbendazole, Ivermectin, and Quercetin when they told him it was hopeless. Being a vet, he had no trouble getting the drugs.
Don't overlook Zinc. I've seen this in a few places: quercetin (as well as quinine or HCQ) primarily amplifies the positive effect of Zinc, which essentially is to clear out toxic cells before they can reproduce. Ivermectin may also have a synergistic effect on Zinc, aside from its formidable antiparasitic effects. I believe 25 mg of Zinc is plenty when combined with any of these agents. Also: I have seen that it is best to space out doses of quercetin and Ivermectin by a few hours. Perhaps someone can confirm or clarify
zinc kills the virus in the cell, but requires an ionophore like hcq or quercetin to get into the cell
Thanks 2nd. Most excellent post.
You mean these 2 wonderful, incredibly cheap drugs; could "deprive" the MegaPharmas of their Evil Profiteering, Price Gouging & affect the Obscene Bi££ion$ bottom line?
More power & kudos to all of your posts 2nd.
Are you also evaluating the work done by Thomas Seyfried in showing cancer’s metabolic vulnerabilities?
My dad was diagnosed with stage 4 liver cancer 4 weeks post booster, given weeks to live. We put him on 12mgs ivm daily for 2 months then 12mgs every other day and he's doing great, no symptoms and it's been almost 2 years. Unfortunately we can't get another scan for him as my mum no longer trusts the NHS. It's good stuff!
"The anti-parasitic drugs fenbendazole, flubendazole, albendazole, and mebendazole have been used safely to treat pinworm and other helminthic infections in humans and animals for decades. The rationale for developing these drugs as cancer therapeutics is their microtubule destabilizing activities.
While evidence for the efficacy of these benzimidazoles is increasing in the scientific literature, social media has exploded with accounts of de-wormer reports showing efficacy as an anti-cancer treatment off prescription. Clearly, scientifically designed studies are needed to evaluate these drugs as anti-cancer agents and provide information to appropriately design clinical trials and applications."
Source: "Potential and mechanism of mebendazole for treatment and maintenance of ovarian cancer", Oct 2020 ncbi.nlm.nih.gov/pmc/articles/PMC8820236/
Forgive if I missed it, but What is the dosage for defeating/preventing cancer? I've been following FLCCC for over two years with Ivm 18mg for my weight once a week for prevention of you know what.
Yes - the FLCCC has a chart depending on a person's weight. But the dosage varies from .02 to .06 mg/Kg. They also said there seemed to be no "toxic" level that had been found. So how does one determine an effective dose for preventing cancer?
It may help to know that there is little cancer in parts of Africa where they take ivermectin once a week to prevent malaria. It stays in the blood longer than a week.
Don't overlook Zinc. I've seen this in a bunch of places: quercetin (as well as quinine or HCQ) primarily amplifies the positive effect of Zinc, which essentially is to clear out toxic cells before they can reproduce. Ivermectin may also have a synergistic effect on Zinc, aside from its inherent parasitic abilities. I believe 25 mg of Zinc is plenty when combined with any of these agents. Also: I have seen that it is best to space out doses of quercetin and Ivermectin by a few hours. Perhaps someone can confirm or clarify
In the Gao et al study (although n=5) it looks like fenben alone is cancer promoting, however, when combined with the vitamins is cancer-reducing. I wonder if this is how big pharma will kill off fenben by saying it's 'dangerous.'
Can you provide a link to this study, please and thank you.
It's the study cited in the article.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2687140/
I really wish 2SG would address this. As far as I know he has not. Makes me wary of fenben but I am not up on the whole situation.
Thank you very much.
I recently posted a comment on one of the fenbendazole can cure cancer substacks, referencing an article which cites numerous other studies that report same/similar alarming issues after taking fenbendazole.. The substack author didn't comment on it there either.
Here is the link... https://adventureswithjodi.com/cancer-pathway_charts/ .
Scroll about halfway down to where it says "1. Thinking of trying Fenbendazole? "
Ms Ledley is an advocate of mega dosing foods nutrients with proven high anti-cancer properties. A frequent contributor on the chrisbeatcancer site/group; her story and that of her husband etc, are worth a read.
From what I can tell she knows her stuff and provides well sourced data to support it.
She provides several studies that report fenbendazole is associated with metastasis issues and more.
Yep. The danger of just taking things at face value.
Thank You very much.
Thanks for this! A lot of great info here.