I’ve not written much lately about the pandemic and the vaccination controversy since I essentially hit a brick wall in digesting and conveying the science on why mass vaccination with these novel and experimental vaccines are such a bad and dangerous approach. Which is ironic since everyone says they are just following “The Science”. I realize now though that we must speak out whether or not ordinary people have any real time for a scientific debate. Most of us are ill equiped to even begin to understand the science so we are easy prey for the charlatans who cloak themselves in “The Science”. After an in depth reading of Dr. Vanden Bossche's latest COVID-19 analysis found here and in PDF form here in a highly technical paper, I’ve come to agree with GVB that we are only a couple of months away from massive morbidity and death in highly vaccinated countries. The clarity of this stage of the SARSCov2 pathogen’s trajectory as GVB describes it in this video interview by Australian Maria Zeee is bracing to say the least. It must be addressed and put out there.
Watch the video first. Listen to what he’s describing as best you can. Then if you can handle technical reading, go over to the PDF and sit with it a few days. These are the concepts in epidemiological terms he centers on:
The virus has its own program and wishing the pandemic was over or that public health authorities and politicians can declare it over on pharmacological whim would be a huge catastrophic blunder. Millions of years of evolutionary interaction between viruses and animals are at play here.
The vaccines have interfered with the natural resolution of the current pandemic.
High infectiousness of the current variant(s) which translates into extreme infectious pressure at a population level on the virus is causing reinfection among primarily vaccinees and in turn a feedback loop of those reinfections is selecting even more fit sub-variants of SARSCov2.
Non-neutralizing antibodies (abs) promoted by the original SARSCov2 strain in Wuhan as delivered by the mRNA and AvvDNA vaccines will not only facilitate the spread of the highly infectious Omicron and its sub-variants but will inevitably (and soon) choose a variant of high VIRULENCE among the vaccinated.
Continued program of mass vaccination enables a perpetual pandemic of high instability that will never get the world to herd immunity - especially the program to vaccinate children and rob the world of a foundation for herd immunity.
I’ve been reading and listening to Vanden Bossche for over a year since the rollout of the vaccines and he’s been right the whole time about the dangers of mass vaccination during a pandemic. He’s described the situation we find ourselves in now and the evolution toward the inevitable immune escape of SARSCov2 through mass vaccination of non-sterilizing vaccine. He is uniquely positioned in his experiences as both a vaccinologist and an immunologist through his diverse career starting out as a veterinarian.
Geert Vanden Bossche
Geert Vanden Bossche received his DVM from the University of Ghent, Belgium, and his PhD degree in Virology from the University of Hohenheim, Germany. He held adjunct faculty appointments at universities in Belgium and Germany. After his career in Academia, Geert joined several vaccine companies (GSK Biologicals, Novartis Vaccines, Solvay Biologicals) to serve various roles in vaccine R&D as well as in late vaccine development.
Geert then moved on to join the Bill & Melinda Gates Foundation’s Global Health Discovery team in Seattle (USA) as Senior Program Officer; he then worked with the Global Alliance for Vaccines and Immunization (GAVI) in Geneva as Senior Ebola Program Manager. At GAVI he tracked efforts to develop an Ebola vaccine. He also represented GAVI in fora with other partners, including WHO, to review progress on the fight against Ebola and to build plans for global pandemic preparedness.
Back in 2015, Geert scrutinized and questioned the safety of the Ebola vaccine that was used in ring vaccination trials conducted by WHO in Guinea. His critical scientific analysis and report on the data published by WHO in the Lancet in 2015 was sent to all international health and regulatory authorities involved in the Ebola vaccination program. After working for GAVI, Geert joined the German Center for Infection Research in Cologne as Head of the Vaccine Development Office. He is at present primarily serving as a Biotech / Vaccine consultant while also conducting his own research on Natural Killer cell-based vaccines.
This is the guy you want to listen to.
What he is attempting to sound the alarm about is highly technical since there is no easy way out of the clusterfuck we’ve gotten ourselves into. I myself find it mind-numbing to visualize the mechanics involved and I like SCIENCE but I feel compelled to try and translate his ideas into digestible pieces. I do think though that he does a pretty good job talking about the impending explosion ahead in that video.
Visualize SARSCov2 virion as the CDC model depicts it; a ball with spikes that function to attach the virion to a cell to inject the fully coded alien RNA into it then take the cell’s machinery over to force the reproduction of the elements of SARSCov2. The spike protein is what makes the virus infectious through its attachment to a receptor called ACE2 on specific cells in the upper respiratory tract called endothelial cells. Endothelial cells with ACE2 receptors present themselves also in the lower respiratory tract and other organs like the lungs, heart, kidneys and liver and along the inside walls of the vascular system.
The vaccines were designed to block the spike protein from attaching to the ACE2 receptors by eliciting newly minted vaccinal abs (antibodies for short). They were designed solely around the functioning of the adaptive immune response ignoring the innate immune response. The adaptive immune system involves the lymph nodes, B-cells in particular, that learn the epitopes (the Legos™, let’s say, that the spike protein presents on its surface that fits into the ACE2 Legos™) and outfit new antibodies aimed at the spike protein’s Receptor Binding Domain (RBD) epitopes. These abs bind to the epitopes and block the virus from efficiently attaching to an ACE2 receptor to gain entry into a cell.
Leaky
Now it’s critical to this description to stop there. The pharmaceutical companies were intent on developing a biologic - a type of genetically enhanced technology used in medicine - aimed solely at one structure of the virus; the spike protein. They didn’t want the thing “live” or able in any way to reproduce so they focused on the one piece that would stop the virus from spreading disease, the mechanism for attachment and cellular entry - the spike. It’s the RBD (Receptor Binding Domain) and its associated proteins that sit upon one portion of the spike that do that dirty work. The other part, and this is important to understand what GVB has his hair on fire about is called the N-Terminal Domain or NTD for short. Both are situated next to each other on the outer surface of the spike protein.
Unfortunately, that strategy of targeting the spike (specifically the RBD) alone was defeated by the evolutionary pressure presented by a leaky vaccine. It had to be completely sterilizing - neutralizing in other words - to prevent survivor virions from escaping and replicating. In that situation the pathogen has the convenience of waiting out an attack and buying enough time to develop a fit mutation that tests itself against the vaccinal antibodies (abs) and then escapes to another host. This is pure Darwin. Immunologists learn this their first year at medical school. We all learned the equivalent about 30 years ago concerning antibiotics and the dangers of allowing super bugs to escape the infected host that fails to sterilize using a full course of the antibiotic. That the mRNA vaccines weren’t sterilizing didn’t seem to bother the developers nor the public health authorities. The endpoints in the Pfizer trials concerned showing proof of some benefit over NOT being vaccinated in terms of moderate disease. They then claimed they could extrapolate those positive results to severe disease and death. In the shifty ways I described in my early pieces about the rollout of the vaccines, they used these endpoints to game the phase III trials so they could get their toe in the door of the FDA for a quick EUA. But the real point here for the sake of underscoring the problem is that these vaccines were never sterilizing as the federal government asked through the NIH and CDC when it solicited bids from Big Pharma for a neutralizing vaccine to end the pandemic. They were leaky. They were a dangerous sham. For a fictional take see the movie “The Third Man” written by Graham Green and directed by Carol Reed on the horrors of using watered down, black market penicillin in post-war Vienna.
They have their 5 year plans and so have I.
The Ferris Wheel
We now have the train wreck of hyper-fit variants and now sub-variants as a direct result of breaking the rules of epidemiology. Reinfections among the vaccinated are now acting like a feedback loop in selecting even more fit sub-variants of SARSCov2. Geert Vanden Bossche predicted all of this a year ago. He has one bone chilling prediction on deck that has very dark consequences for the vaccinated. I think we are in the beginning stages of that spiral:
The antibodies from the B-cells that retained the memory of the surface of the RBD - the epitopes or Legos™ are no longer neutralizing the variants. Hence infectiousness has been ramped up way past the infectiousness of chicken pox. That’s why everybody and their sister and grandkid is getting their second, maybe third infection after being vaxxed, boosted maybe even twice now. This is happening with friends and family as I type here in Michigan where cases are shooting up the last three weeks. The authorities and media aren’t so alarmed this time around because the infections seem to be mild and hospitalization and death is low relative to the infectious pressure in the population (and the midterms are looming for the party in power). As Geert points out, some are even claiming this is a bonus toward herd immunity ESPECIALLY if vaccinated. Best of both worlds so to say. But this phenomenon will be fleeting very quickly as GVB makes clear.
The N-Terminal Domain (NTD) is the other structure of the spike protein that will be the vehicle for this catastrophe. The now non-neutralizing abs can attach themselves to the NTD rather than the RBD which was their initial target before the virus learned to resist the RBD epitope blocking. This change actually helps the vaccinated (but only for the moment) downstream from the upper respiratory tract by preventing the virus from causing trans infection in the lower respiratory tract and organs beyond. They do this by binding to the virions’ exposed NTD that get attached to the dendrite cells assigned to present these antigens to the lymph nodes and signal an immune response. These DC’s also make their way to the lower respiratory tract (LRT). Thus the diminished amount of disease caused by Omicron infection in the LRT because the non-neutralizing abs are binding to the NTD epitopes preventing a phenomenon known as Antibody Dependant Enhanced Disease (ADED) from taking hold - a plus for the vaccinated. This is a temporary situation because the evolutionary pressure on the spike protein from constantly recalled non-neutralizing antibodies will quickly change conditions on the RBD and the residual protection from severe disease among the vaccinated that mitigates the interaction of the NTD and the non-neutralizing abs will overnight flip into a bad ADED scenario.
Most self-limiting respiratory RNA viruses use sugars - glycans - as part of their evolutionary strategies to defeat neutralizing abs. They essentially cover their infection “hooks” like the SARSCov2 RBD with a camouflage of a molecule that the immune system sees as “self-like” or part of the host. An ingenious tactic of stealth coating so-to-say. That evolution is ongoing now with SARSCov2. When it is complete no vaccine that targets the RBD - or the hook on the spike protein - will be able to neutralize the pathogen for being blind to its epitopes. Along with the complete uselessness of the non-neutralizing abs elicited by the vaccines, these very same abs produced each time a vaccinee gets re-infected will actually aid the virus in invading the LRT and replicating inside immune cells like macrophages and even on the surfaces of organ tissue presenting ACE2 receptors - the ADED described above - augmenting and amplifying Covid-19 disease.
Visualize the spike protein that recognizes an ACE2 receptor and attaches to a cell. It then undergoes conformational changes to erect a gangway into the cell. The infamous “furin cleavage site” (which no coronavirus to date ever had genetic code to produce as a structure of invasion and is a classic sign of genetic engineering - see The Bat Lady and Origin story of SARSCov2) starts an unfolding process that uses the invaded cell’s amino acids to help clip off the now no longer needed hook so that a tunnel-like structure behind it can directly inject the virion’s RNA into the cell’s protoplasm. As GVB describes in his paper, non-neutralizing abs can cause the same effect when they attach to the RBD before a virion gets anywhere near an ACE2 receptor. The virion unfolds at the spike RBD. When it does so the conformational changes can expose the part of the spike, the NTD, that was shielded by the RBD structure and since that section is not coated by glycan sugars it can bind to the non-neutralizing abs floating around because reinfection jump started the adaptive immune response and injected these now useless abs into the bloodstream. This binding at the NTD is different from the binding I earlier described there as helpful to vaccinees in avoiding severe disease in the LRT and beyond. This time the virion’s RBD is in the open position - like a blooming flower - because the non-neutralizing abs have somewhat attached and triggered that response. This open configuration exposes the other structure - the NTD - which is covered now with the same useless abs. The white blood cells called dendritic cells (DC) that are assigned to pick up antigens in the bloodstream grab at the free floating virions now in this unusual configuration with antibodies attached and presented on the outside of the DC attempt to take this information to the lymph nodes. They also inadvertantly take this virion/antibody fusion into the LRT via the bloodstream where it can cause trans-infection; meaning these new structures can invade certain OTHER cells by means of alternative attachment to enzymes presented outside those cells USING the virion’s NTD as the Trojan Horse per say. This will mostly be a phenomenon of the vaccinated since they are the ones producing the non-neutralizing abs that the original vaccine elicits… forever. The unvaccinated will train on the newer variants with an ever enhanced innate immune response in the URT that knocks down the infections (and, yes, reinfections) long before the dendritic cells have to do any work that would drag virions into the LRT. The adaptive immune system will also help the unvaccinated after their first exposure and infection since their immune systems weren’t primed by the re-engineered Wuhan strain of spike protein the mRNA vaccines genetically fabricated and will be able to assist the innate response in subsequent infections with a one/two punch sterilizing effect. They have not experienced original antigenic sin - through exposure to a vaccine at least.
That’s as far as I will interpret. You must read the paper to fully understand the details and the consequences. His message now is quite alarming:
The frequency of reinfections with the background of high infectious pressure in the population has a direct effect of when individuals have a level of response from their lymphatic system in producing non-neutralizing abs. If these abs are constantly being recalled into the bloodstream based on the vaccines original coded forumula for the Wuhan strain of SARSCov2 they will inevitably lead to ADED (Antibody Dependant Enhancement of Disease) among the vaccinated. “Inevitably” in a highly mutable virus’s timeframe means almost next week. I can’t sugar coat it but just a few more sugar coatings on the RBD would do it. GVB uses the word “fulminate” to emphasize how quickly and broadly the outbreak of such a disaster would go down throughout the highly vaccinated countries almost in sync. In any event, it will take off very quickly and without the proper preparations to handle the panic and response to massive hospitalization and death. Look around you. Observe how many people you directly know are experiencing breakthrough after breakthrough infection no matter how mild. People I know are saying the flu season seems to be extended this year. I’ve looked at that data at the CDC and the flu trackers say we didn’t have much of a flu season this year (down to 11% of a typical season b/n 2010-2011 - 4200 deaths from an baseline avg of @37,000) but they did extend their surveillance because of an uptick in March. Still the map shows almost all green.
I add this data because I’ve heard it repeated often enough in the past few weeks and when refuted as an explanation too many times I get the feeling that most of this hand waiving anecdotal “science” is being ingested via MSM media and pubic health authorities. As the new Covid cliche goes: It’s #NotTheFlu. It’s a symptom of the mass formation the populace has succumbed to that it appears inconceivable that the vaccinated and now boosted can get infected and reinfected by SARSCov2.
That final point about re-infection is the linchpin to understand how this all accelerates in the next few weeks. The virus is producing shorter and shorter intervals between surges in vaccinated countries. It’s also narrowing down its dominant variants to sub-variants of Omicron. We are presently in what GVB refers to as the “fitness valley”, the lull so to speak, of high infectious pressure but mild symptomatic infection and high titers of non-neutralizing abs in the general population. This is the final tryouts of the mutation that totally escapes the immune system with the attribute of high virulance for the vaccinated. The signal to watch for isn’t the now useless surveillance systems of the CDC counts on daily, weekly cases but the hospitalization numbers. Most people aren’t reporting infections and positive tests. I am sure here in Michigan that the case numbers are close right now to our largest surge over the holidays or even well past it (officially at @4,000/day as of 5/18 with a positivity rate of 17%). The hospitals will not be able hide the surge in admittance over severe COVID-19 infections. Nor will the health system be enabled to continue the farce that this is a pandemic of the unvaccinated since almost exclusively the severe outcomes will effect the vaccinated. GVB points this out not to stigmitize any treatment group (we are still part of a grand experiment let’s not forget) but to illustrate that a virus, this SARSCov2 virus, can exploit the so-called genius of novel experimental genomic therapy when depoyed on a mass scale. The road to hell is paved with good intentions (and liability protected profit) as Harry Lime might say.
Great GVB video interview with host Maria!!! GVB emphasized the need for early treatment with antivirals several times but he never mentioned the name of those antivirals. Do you know which antivirals he recommends?
I read the article and am now absorbing your very well articulated and explained content. I still need to watch the GVB video and review his PDF analysis. My question for now is how does this all affect the unvaccinated who have not yet had an infection. Should the unvaxed consider purposely getting the mild omicron variant currently circulating to protect against a possible more virulent mutation? Does GVD say anything of this?