NERF? Well, how about Nrf2 (Nuclear factor erythroid 2-related factor 2)? In earlier posts it was described how oxidative stress on cells (either from spike protein, EMF radiation or toxin) can cause dysregulation of miRNA (microRNA - Dicer & Drosha) which in-turn cause many forms of cellular disfunction. Specifically we need to understand the complexity of the Nrf2 system, which lies in the manner in which it is regulated in its expression, including miRNA influences, antioxidant protection, carcinogenesis protection, tumor suppression, cytoprotection of genes, glucose metabolism and dozens of other complicated cellular activities.
Specifically, dysregulated intracellular miRNAs result in the aggravation of myocarditis (below figure). Several dysregulated miRNAs are involved in the etiology and pathogenesis of myocarditis, show phase-dependent changes, and correlate with viral infection, immune status, fibrosis, destruction of cardiomyocytes, arrhythmias, cardiac functions, and outcomes.
“Researches have shown that a systemic Th1/Th2 imbalance exist during the clinical phase of myocarditis. Analysis of peripheral CD4+ T cells in a patient with acute myocarditis demonstrated that Th1 was dominant during the acute phase and coincided with increased serum levels of creatine kinase (CK), while Th2 predominated during the recovery phase and was accompanied by decreased CK levels. Consistent with this, restoring the Th1/Th2 inflammatory cytokine balance hindered the progression of autoimmune myocarditis” (link)
Basic summary: miRNA co-regulate the complex Nrf2 system that touches several systems. One of these dysregulations of miRNA through oxidative stress cause cardiomyocyte formation/destruction - myocarditis.
Natural Derivative Solutions
In order to re-regulate our Nrf2 systems, reduce risks and also undo cardiomyocyte degradation, we can utilize Heme-Oxygenase 1 Inducers. Simple right, just increase your Heme-Oxygenase 1 Inducers and you are set. (-_-)ゞ
Or…
Increase intake of the following naturally derived Nrf2 regulating solutions:
Circadian Cycle - NF-kB (inflammatory protein) - Good night’s sleep (dark room - no EMF)
Fulvic Acid, Humic Substances, Polyphenols - red wines & dark chocolate
Fatty Acids - nuts & fish
Quercetin - flavonoid commonly found in fruits and vegetables - red onion & tea leaves
Curcumin - polyphenolic root
Carnosic Acid and Carnosol - oxidative product (phenolic) - rosemary & salvia
Resveratrol - polyphenol present in many fruits and vegetables - grapes, cocoa, peanuts, berries & wine
Anthocyanins - flavonoid phenolic compounds - present in vegetables, flowers, and fruits such as berries
Epigallocatechin Gallate - polyphenol - EGCG - green tea
Phlorotannins - tannins - brown seaweed
Celastrol - quinone methide triterpene - root of the Thunder God Vine (Tripterygium wilfordii) and Celastrus regelii plant
Caffeic Acid Phenethyl Ester - antioxidant - honeybee propolis
Capsaicin - oleoresin - active ingredient of chili peppers
Garlic - derived organosulfur compounds - garlic (allium sativum) essential oil, mustard, asafoetida, and other food extracts
Isothiocyanates - antioxidant - cruciferous vegetables (broccoli etc.)
“It was demonstrated in this article that high intakes of fruit and vegetables are associated with a decrease in cardiovascular diseases via endothelial protection. Thus the most important fruit/vegetables and bioactive compounds to prevent endothelial diseases are berries, apples, virgin olive oil, tomatoes, soybeans, and polyphenols, carotenoids and unsaturated fatty acids, respectively. The bioactive compounds from fruit and vegetables provide endothelial protection through the following mechanisms: improved eNOS/NO bioavailability, attenuates oxidative stress, inhibited NF-κB pathway and decreased cell adhesion molecules expression. In table SI (Supplementary Material) we show endothelial cell protection by natural bioactive compounds from fruit and vegetables.”
I'm not trying to push my luck here, but I ascribe to the idea of "listening" to what ones body tells you it needs and wants and I'm pleased to read that many of the simple things you suggest are the same things my body tells me it wants day after day.
As for Capsaicin, that has been a hobby of mine this past year as I grew ghost peppers from seed even though most of the peppers ended up being tabasco hybrid plants, but boy were they profligate (edit:
ha, ha - I mean prolific) and I saved almost all the peppers in a concentrate that I jarred for future use. Ghost Peppers, tobasco, cayenne, banana, jalapeno, and others all mixed together gloriously with vinegar salt and tomato concentrate - it is easy to grow this if your soil is fertile and well taken care of with diligence and love. My friend gave me the ghost pepper seeds and at first I complained about the prolific tobasco peppers, but now I appreciate them for what they were and next year I will grow them again.
Of the other items on your list, I enjoy grapes just about every day and that includes natural grapes in the morning usually with breakfast and grapes via wine both white and red on many days I won't deny. I am a big fan of almonds and enjoy pistachios as well.
One time, when I was on a job near Bakersfield CA we went to the Wonderful factory cafeteria (literally), and let me tell you that place was nice! All the trees, the almond ones and pistachio ones as well were nearby. If memory serves, but maybe it doesn't that was the same trip where we met with the fella who had a guacamole farm (avocados) - there is big money in that little did I know.
Like I said - I listen to my body and I trust it to tell me what it wants. Today I want some resolution, but I don't always get what I want.
Keep it coming and I'll study up on this - it is appreciated......I think solutions is what we need because a lot of harm has been sent out and caused and there must be remedy. There just must be.
Sometimes the best remedy though is Justified Retribution if you know what I mean.
Best to you and I'll try to stay abreast of this and that.
BK
Excellent and much needed, thank you!